Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men.
Identifieur interne : 000554 ( Main/Exploration ); précédent : 000553; suivant : 000555Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men.
Auteurs : Joël Constans [France] ; Catherine Bennetau-Pelissero [France] ; Jean-François Martin [France] ; Edmond Rock [France] ; Andrzej Mazur [France] ; Aurélie Bedel [France] ; Christine Morand [France] ; Annie M. Bérard [France]Source :
- Clinical nutrition (Edinburgh, Scotland) [ 1532-1983 ] ; 2015.
English descriptors
- KwdEn :
- Antioxidants (administration & dosage), Antioxidants (analysis), Apolipoprotein A-I (blood), Ascorbic Acid (administration & dosage), Ascorbic Acid (analysis), Biomarkers (blood), Biomarkers (urine), Body Mass Index, Cardiovascular Diseases (prevention & control), Cholesterol, HDL (blood), Cholesterol, LDL (blood), Citrus sinensis (chemistry), Cross-Over Studies, Flavonoids (administration & dosage), Flavonoids (blood), Fruit and Vegetable Juices (analysis), Hesperidin (administration & dosage), Hesperidin (blood), Humans, Hypercholesterolemia (diet therapy), Male, Middle Aged, Oxidative Stress, Phytochemicals (administration & dosage), Phytochemicals (analysis), Reactive Oxygen Species, Risk Factors, Single-Blind Method, Triglycerides (blood).
- MESH :
- chemical , administration & dosage : Antioxidants, Ascorbic Acid, Flavonoids, Hesperidin, Phytochemicals.
- chemical , analysis : Antioxidants, Ascorbic Acid, Phytochemicals.
- chemical , blood : Apolipoprotein A-I, Biomarkers, Cholesterol, HDL, Cholesterol, LDL, Flavonoids, Hesperidin, Triglycerides.
- chemical , urine : Biomarkers.
- analysis : Fruit and Vegetable Juices.
- chemistry : Citrus sinensis.
- diet therapy : Hypercholesterolemia.
- prevention & control : Cardiovascular Diseases.
- Body Mass Index, Cross-Over Studies, Humans, Male, Middle Aged, Oxidative Stress, Reactive Oxygen Species, Risk Factors, Single-Blind Method.
Abstract
Blond orange juice is the most consumed fruit juice in the world. It is a source of hesperidin, a bioavailable flavonoid reported to exhibit potential vascular protective actions. However, the specific impact on vascular function of Citrus phytomicronutrients, is unknown. For the first time, we investigated the effects of blond orange juice compared with a control beverage mimicking the composition of orange juice (including Vitamin C but no phytomicronutrients), on antioxidant markers, cardiovascular risk factors and endothelial function.
DOI: 10.1016/j.clnu.2014.12.016
PubMed: 25865966
Affiliations:
- France
- Aquitaine, Auvergne (région administrative), Auvergne-Rhône-Alpes, Nouvelle-Aquitaine
- Bordeaux, Clermont-Ferrand
- Université de Bordeaux
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Le document en format XML
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Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Bedel, Aurelie" sort="Bedel, Aurelie" uniqKey="Bedel A" first="Aurélie" last="Bedel">Aurélie Bedel</name><affiliation wicri:level="4"><nlm:affiliation>CHU - Université de Bordeaux, ERU «Facteurs de risque vasculaires», case 49, 146 rue Léo Saignat, F-33076 Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU - Université de Bordeaux, ERU «Facteurs de risque vasculaires», case 49, 146 rue Léo Saignat, F-33076 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name><affiliation wicri:level="3"><nlm:affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Berard, Annie M" sort="Berard, Annie M" uniqKey="Berard A" first="Annie M" last="Bérard">Annie M. Bérard</name><affiliation wicri:level="4"><nlm:affiliation>CHU - Université de Bordeaux, ERU «Facteurs de risque vasculaires», case 49, 146 rue Léo Saignat, F-33076 Bordeaux, France. 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INSERM, Physiopathologie de la plasticité neuronale, U862, F-33077 Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Physiopathologie de la plasticité neuronale, U862, F-33077 Bordeaux, France; INSERM, Physiopathologie de la plasticité neuronale, U862, F-33077 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Martin, Jean Francois" sort="Martin, Jean Francois" uniqKey="Martin J" first="Jean-François" last="Martin">Jean-François Martin</name><affiliation wicri:level="3"><nlm:affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Rock, Edmond" sort="Rock, Edmond" uniqKey="Rock E" first="Edmond" last="Rock">Edmond Rock</name><affiliation wicri:level="3"><nlm:affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name><affiliation wicri:level="3"><nlm:affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Bedel, Aurelie" sort="Bedel, Aurelie" uniqKey="Bedel A" first="Aurélie" last="Bedel">Aurélie Bedel</name><affiliation wicri:level="4"><nlm:affiliation>CHU - Université de Bordeaux, ERU «Facteurs de risque vasculaires», case 49, 146 rue Léo Saignat, F-33076 Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU - Université de Bordeaux, ERU «Facteurs de risque vasculaires», case 49, 146 rue Léo Saignat, F-33076 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name><affiliation wicri:level="3"><nlm:affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Berard, Annie M" sort="Berard, Annie M" uniqKey="Berard A" first="Annie M" last="Bérard">Annie M. Bérard</name><affiliation wicri:level="4"><nlm:affiliation>CHU - Université de Bordeaux, ERU «Facteurs de risque vasculaires», case 49, 146 rue Léo Saignat, F-33076 Bordeaux, France. Electronic address: annie.berard@u-bordeaux2.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU - Université de Bordeaux, ERU «Facteurs de risque vasculaires», case 49, 146 rue Léo Saignat, F-33076 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author></analytic><series><title level="j">Clinical nutrition (Edinburgh, Scotland)</title><idno type="eISSN">1532-1983</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants (administration & dosage)</term><term>Antioxidants (analysis)</term><term>Apolipoprotein A-I (blood)</term><term>Ascorbic Acid (administration & dosage)</term><term>Ascorbic Acid (analysis)</term><term>Biomarkers (blood)</term><term>Biomarkers (urine)</term><term>Body Mass Index</term><term>Cardiovascular Diseases (prevention & control)</term><term>Cholesterol, HDL (blood)</term><term>Cholesterol, LDL (blood)</term><term>Citrus sinensis (chemistry)</term><term>Cross-Over Studies</term><term>Flavonoids (administration & dosage)</term><term>Flavonoids (blood)</term><term>Fruit and Vegetable Juices (analysis)</term><term>Hesperidin (administration & dosage)</term><term>Hesperidin (blood)</term><term>Humans</term><term>Hypercholesterolemia (diet therapy)</term><term>Male</term><term>Middle Aged</term><term>Oxidative Stress</term><term>Phytochemicals (administration & dosage)</term><term>Phytochemicals (analysis)</term><term>Reactive Oxygen Species</term><term>Risk Factors</term><term>Single-Blind Method</term><term>Triglycerides (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antioxidants</term><term>Ascorbic Acid</term><term>Flavonoids</term><term>Hesperidin</term><term>Phytochemicals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antioxidants</term><term>Ascorbic Acid</term><term>Phytochemicals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Apolipoprotein A-I</term><term>Biomarkers</term><term>Cholesterol, HDL</term><term>Cholesterol, LDL</term><term>Flavonoids</term><term>Hesperidin</term><term>Triglycerides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Fruit and Vegetable Juices</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Hypercholesterolemia</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Body Mass Index</term><term>Cross-Over Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Oxidative Stress</term><term>Reactive Oxygen Species</term><term>Risk Factors</term><term>Single-Blind Method</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Blond orange juice is the most consumed fruit juice in the world. It is a source of hesperidin, a bioavailable flavonoid reported to exhibit potential vascular protective actions. However, the specific impact on vascular function of Citrus phytomicronutrients, is unknown. For the first time, we investigated the effects of blond orange juice compared with a control beverage mimicking the composition of orange juice (including Vitamin C but no phytomicronutrients), on antioxidant markers, cardiovascular risk factors and endothelial function.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li><li>Clermont-Ferrand</li></settlement><orgName><li>Université de Bordeaux</li></orgName></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Constans, Joel" sort="Constans, Joel" uniqKey="Constans J" first="Joël" last="Constans">Joël Constans</name></region><name sortKey="Bedel, Aurelie" sort="Bedel, Aurelie" uniqKey="Bedel A" first="Aurélie" last="Bedel">Aurélie Bedel</name><name sortKey="Bennetau Pelissero, Catherine" sort="Bennetau Pelissero, Catherine" uniqKey="Bennetau Pelissero C" first="Catherine" last="Bennetau-Pelissero">Catherine Bennetau-Pelissero</name><name sortKey="Berard, Annie M" sort="Berard, Annie M" uniqKey="Berard A" first="Annie M" last="Bérard">Annie M. Bérard</name><name sortKey="Martin, Jean Francois" sort="Martin, Jean Francois" uniqKey="Martin J" first="Jean-François" last="Martin">Jean-François Martin</name><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name><name sortKey="Rock, Edmond" sort="Rock, Edmond" uniqKey="Rock E" first="Edmond" last="Rock">Edmond Rock</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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